Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00616
Abstract: Bacterial fatty acid synthases are promising antibacterial targets against multidrug-resistant pathogens. Platensimycin (PTM) is a potent FabB/FabF inhibitor, while its poor pharmacokinetics hampers the clinical development. In this study, a focused library of PTM derivatives… read more here.
Keywords: late stage; functionalization platensimycin; antibacterial activity; stage functionalization ... See more keywords
Obtaining Medical Textiles Based on Viscose and Chitosan/Zinc Nanoparticles with Improved Antibacterial Properties by Using a Dielectric Barrier Discharge
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14194152
Abstract: This study aimed to obtain functional viscose textiles based on chitosan coatings with improved antibacterial properties and washing durability. For that reason, before functionalization with chitosan/zinc nanoparticles (NCH+Zn), the viscose fabric was modified by nonthermal… read more here.
Keywords: chitosan zinc; textiles based; zinc nanoparticles; antibacterial properties ... See more keywords