Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115511
Abstract: Hesperetin (HSP) has excellent biological activities with poor water solubility which limits its clinical development. In this study, we successfully prepared a novel, self-assembled micelle based on Rebaudioside A (RA) for oral delivery of HSP… read more here.
Keywords: bioavailability; hsp; breast cancer; self assembled ... See more keywords
Long-term sustained release Poly(lactic-co-glycolic acid) microspheres of asenapine maleate with improved bioavailability for chronic neuropsychiatric diseases
Sign Up to like & getrecommendations! Published in 2020 at "Drug Delivery"
DOI: 10.1080/10717544.2020.1815896
Abstract: Abstract Schizophrenia and bipolar disorder are severe chronic neuropsychiatric diseases, affecting hundreds of millions of people worldwide. Asenapine maleate (ASM) has been demonstrated as a safe and effective therapeutic agent under twice-daily administration. However, lower… read more here.
Keywords: chronic neuropsychiatric; neuropsychiatric diseases; asm; bioavailability ... See more keywords
Fabrication and Evaluation of Quercetin Nanoemulsion: A Delivery System with Improved Bioavailability and Therapeutic Efficacy in Diabetes Mellitus
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DOI: 10.3390/ph15010070
Abstract: The current study was intended to fabricate and evaluate ultrasonically assisted quercetin nanoemulsion (Que-NE) for improved bioavailability and therapeutic effectiveness against diabetes mellitus in rats. Ethyl oleate, Tween 20, and Labrasol were chosen as oil,… read more here.
Keywords: improved bioavailability; bioavailability; nanoemulsion; quercetin nanoemulsion ... See more keywords
Improved Bioavailability of Montelukast through a Novel Oral Mucoadhesive Film in Humans and Mice
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13010012
Abstract: The leukotriene receptor antagonist Montelukast (MTK) is an approved medication for the treatment of asthma and allergic rhinitis. The existing marketed tablet forms of MTK exhibit inconsistent uptake and bioavailability, which partially explains the presence… read more here.
Keywords: mucoadhesive film; improved bioavailability; film; montelukast ... See more keywords