Efficient Development of Sorafenib Tablets with Improved Oral Bioavailability Enabled by Coprecipitated Amorphous Solid Dispersion.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.121216
Abstract: An amorphous solid dispersion (ASD) of sorafenib (SOR) in hydroxypropyl methylcellulose acetate succinate (HPMC-AS), prepared by coprecipitation, was used to develop an immediate release tablet with improved oral bioavailability. An ASD of 40% drug loading… read more here.
Keywords: oral bioavailability; solid dispersion; improved oral; bioavailability ... See more keywords
Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01383
Abstract: Blocking the entry of an HIV-1 targeting CCR5 coreceptor has emerged as an attractive strategy to develop HIV therapeutics. Maraviroc is the only CCR5 antagonist approved by FDA; however, serious side effects limited its clinical… read more here.
Keywords: ccr5; oral bioavailability; hiv; improved oral ... See more keywords
General dental practice and improved oral health: is there a win-win for both the professional establishment and government?
Sign Up to like & getrecommendations! Published in 2020 at "British Dental Journal"
DOI: 10.1038/s41415-020-1448-3
Abstract: General dental practice in the United Kingdom has been in a state of unrest for over two decades, with practitioners having been confronted by two contract changes. The latest contract change of 2006 resulted in… read more here.
Keywords: dental practice; general dental; improved oral; practice improved ... See more keywords
SmartFilm Tablets for Improved Oral Delivery of Poorly Soluble Drugs
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DOI: 10.3390/pharmaceutics14091918
Abstract: (1) Background: Numerous oral drugs exhibit limited bioavailability due to their poor solubility and poor intestinal permeability. The smartFilm technology is an innovative approach that improves the drug aqueous solubility via incorporating the drug in… read more here.
Keywords: intestinal permeability; smartfilm tablets; curcumin; soluble drugs ... See more keywords
Candesartan cilexetil loaded nanodelivery systems for improved oral bioavailability.
Sign Up to like & getrecommendations! Published in 2017 at "Therapeutic delivery"
DOI: 10.4155/tde-2016-0063
Abstract: Candesartan cilexetil (CC), an antihypertensive drug, has low oral bioavailability due to poor solubility and hepatic first-pass metabolism. These are major limitations in oral delivery of CC. Several approaches are known to reduce the problems… read more here.
Keywords: candesartan cilexetil; oral bioavailability; improved oral; delivery ... See more keywords