Carba Analogues of Flupirtine and Retigabine with Improved Oxidation Resistance and Reduced Risk of Quinoid Metabolite Formation
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DOI: 10.1002/cmdc.202200262
Abstract: The KV7 potassium channel openers flupirtine and retigabine have been valuable options in the therapy of pain and epilepsy. However, as a result of adverse reactions, both drugs are currently no longer in therapeutic use.… read more here.
Keywords: improved oxidation; carba analogues; flupirtine retigabine; oxidation resistance ... See more keywords
Significantly improved oxidation of bio-based furans into furan carboxylic acids using substrate-adapted whole cells
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DOI: 10.1016/j.jechem.2019.04.025
Abstract: Abstract Furan carboxylic acids are important building blocks in polymer and fine chemical industries. In this work, a simple substrate adaptation strategy was applied to improve the catalytic performances of Comamonas testosteroni SC1588 cells for… read more here.
Keywords: furancarboxylic acid; significantly improved; carboxylic acids; furan carboxylic ... See more keywords