Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies
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DOI: 10.1016/j.ejmech.2021.113584
Abstract: Replication of SARS-CoV-2, the coronavirus causing COVID-19, requires a main protease (Mpro) to cleave viral proteins. Consequently, Mpro is a target for antiviral agents. We and others previously demonstrated that GC376, a bisulfite prodrug with… read more here.
Keywords: improved sars; mpro inhibitors; cov mpro; solubility ... See more keywords