Understanding the immuno-biology of oesophageal adenocarcinoma: Towards improved therapeutic approaches.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2021.102219
Abstract: With an incidence that is constantly rising, oesophageal adenocarcinoma (OAC) is becoming an increasing health burden worldwide. Although significant advances in treatment regimens have improved patient outcomes, survival rates for this deadly cancer remain unsatisfactory.… read more here.
Keywords: oesophageal adenocarcinoma; treatment; therapeutic approaches; biology ... See more keywords
Improved therapeutic efficiency of photothermal treatment and nursing care in prostate cancer by DOX loaded PEG coated Cu@Se nano-hybrid vesicle
Sign Up to like & getrecommendations! Published in 2020 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2020.02.022
Abstract: Abstract Cancer is one of the major life threatening diseases, with higher mortality rate and morbidity. It is always a challenge for effective drug delivery and release of drug in specific tumor sites. Therefore to… read more here.
Keywords: prostate cancer; dox; cancer; therapeutic efficiency ... See more keywords
Bioorthogonal Chemical Ligation Creates Synthetic Antibodies with Improved Therapeutic Potency
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.3c00240
Abstract: Antibodies, also known as immunoglobulins, are proteins secreted by immune cells to specifically bind foreign antigens, often from invading species. Immunoglobulin G (IgG), one of the major classes of antibodies, is composed of two heavy… read more here.
Keywords: chemical ligation; improved therapeutic; chemistry; antibodies improved ... See more keywords
Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41487
Abstract: Thiazolidinediones (TZD) function as potent anti-diabetic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ), but their therapeutic benefits are compromised by severe side effects. To address this concern, here… read more here.
Keywords: ppar; vsp; selective ppar; novel selective ... See more keywords
Phosphatase-triggered cell-selective release of a Pt(iv)-backboned prodrug-like polymer for an improved therapeutic index.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials science"
DOI: 10.1039/c6bm00935b
Abstract: We describe here the synthesis and cell-selective delivery of a cationic Pt(iv)-backboned prodrug-like polymer P(DSP-DAEP). P(DSP-DAEP) features excellent aqueous solubility, unusually high (44.5%) drug loading, can be rapidly reduced to release the active cisplatin, and… read more here.
Keywords: like polymer; cell selective; prodrug like; backboned prodrug ... See more keywords
Tunable biomaterials for myocardial tissue regeneration: promising new strategies for advanced biointerface control and improved therapeutic outcomes.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d1bm01641e
Abstract: Following myocardial infarction (MI) and the natural healing process, the cardiac mechanostructure changes significantly leading to reduced contractile ability and resulting in additional pressure on the heart muscle thereby increasing the risk of heart failure… read more here.
Keywords: improved therapeutic; biomaterials myocardial; myocardial tissue; tunable biomaterials ... See more keywords
Improved therapeutic index of an acidic pH-selective antibody
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2021.2024642
Abstract: ABSTRACT Although therapeutically efficacious, ipilimumab can exhibit dose-limiting toxicity that prevents maximal efficacious clinical outcomes and can lead to discontinuation of treatment. We hypothesized that an acidic pH-selective ipilimumab (pH Ipi), which preferentially and reversibly… read more here.
Keywords: selective antibody; therapeutic index; improved therapeutic; acidic selective ... See more keywords
Do catalytic nanoparticles offer an improved therapeutic strategy to combat dental biofilms?
Sign Up to like & getrecommendations! Published in 2017 at "Nanomedicine"
DOI: 10.2217/nnm-2016-0400
Abstract: Challenges for oral biofilm control & dental caries prevention According to epidemiological data from the WHO, 60–90% of school children and the majority of adults have dental caries (‘toothdecay’) worldwide, often causing pain and discomfort… read more here.
Keywords: nanoparticles offer; offer improved; dental caries; strategy ... See more keywords