Apoptotic Body-Mediated Intracellular Delivery Strategy for Enhanced STING Activation and Improved Tumor Immunogenicity.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.1c03996
Abstract: Agonists of stimulators of interferon genes (STING) are a promising class of immunotherapeutics that trigger potent innate immunity. However, the therapeutic efficacy of conventional STING agonists, such as 2',3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), is severely… read more here.
Keywords: activation improved; enhanced sting; improved tumor; sting activation ... See more keywords
Improved tumor vasculature for immunotherapy
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DOI: 10.1126/science.365.6453.554-q
Abstract: Cancer Dysfunctional vasculature in tumors reduces oxygenation and access to nutrients and prevents immune cell infiltration, which can limit immunotherapy. Cellular components of blood and lymphatic vessels can also directly modulate antitumor immune responses. In… read more here.
Keywords: immunotherapy; improved tumor; vasculature; antitumor ... See more keywords
Molecular Tuning of IR-786 for Improved Tumor Imaging and Photothermal Therapy
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DOI: 10.3390/pharmaceutics14030676
Abstract: A tumor-targeted near-infrared (NIR) fluorophore CA800Cl was developed based on commercially available IR-786 by modulating its physicochemical properties. IR-786, a hydrophobic cationic heptamethine cyanine fluorophore, was previously recognized as a mitochondria-targeting NIR agent with excellent… read more here.
Keywords: 786 improved; tuning 786; improved tumor; molecular tuning ... See more keywords
Improved Tumor Uptake by Optimizing Liposome Based RES Blockade Strategy
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DOI: 10.7150/thno.18078
Abstract: Minimizing the sequestration of nanomaterials (NMs) by the reticuloendothelial system (RES) can enhance the circulation time of NMs, and thus increase their tumor-specific accumulation. Liposomes are generally regarded as safe (GRAS) agents that can block… read more here.
Keywords: optimizing liposome; tumor uptake; improved tumor; uptake optimizing ... See more keywords
Improved Tumor Targeting and Longer Retention Time of NIR Fluorescent Probes Using Bioorthogonal Chemistry
Sign Up to like & getrecommendations! Published in 2017 at "Theranostics"
DOI: 10.7150/thno.20912
Abstract: The traditional labeling method for targeted NIR fluorescence probes requires directly covalent-bonded conjugation of targeting domains and fluorophores in vitro. Although this strategy works well, it is not sufficient for detecting or treating cancers in… read more here.
Keywords: click chemistry; chemistry; improved tumor; tumor targeting ... See more keywords