chainCleaner improves genome alignment specificity and sensitivity
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx024
Abstract: Motivation: Accurate alignments between entire genomes are crucial for comparative genomics. However, computing sensitive and accurate genome alignments is a challenging problem, complicated by genomic rearrangements. Results: Here we present a fast approach, called chainCleaner,… read more here.
Keywords: chaincleaner improves; genome alignments; sensitivity; improves genome ... See more keywords
Ancestry adjustment improves genome-wide estimates of regional intolerance.
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac050
Abstract: Genomic regions subject to purifying selection are more likely to carry disease causing mutations than regions not under selection. Cross species conservation is often used to identify such regions but with limited resolution to detect… read more here.
Keywords: ancestry adjustment; ancestry; adjustment improves; intolerance ... See more keywords