A novel cell-penetrating peptide targeting calpain-cleavage of PSD-95 induced by excitotoxicity improves neurological outcome after stroke
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DOI: 10.7150/thno.60701
Abstract: Postsynaptic density protein-95 (PSD-95) is a multidomain protein critical to the assembly of signaling complexes at excitatory synapses, required for neuronal survival and function. However, calpain-processing challenges PSD-95 function after overactivation of excitatory glutamate receptors… read more here.
Keywords: cleavage; excitotoxicity; induced excitotoxicity; cell penetrating ... See more keywords