Haematological cancer: Lenalidomide improves survival after ASCT
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/nrclinonc.2017.135
Abstract: The outcomes of a phase II, single-arm study involving patients with microsatellite-unstable (MSI) metastatic colorectal cancer receiving treatment with nivolumab reveal high levels of effectiveness. In a heavily pretreated population, 23 patients (31% of the… read more here.
Keywords: survival asct; improves survival; haematological cancer; cancer ... See more keywords
Sarcoma: Local hyperthermia improves survival
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/nrclinonc.2018.38
Abstract: Patients with localized high-risk soft-tissue sarcoma (STS) often have disease relapse after local treatment. Neoadjuvant chemotherapy (NACT) improves the survival outcomes of these patients, although emerging data suggest that additional regional hyperthermia (RHT) can further… read more here.
Keywords: nact alone; hyperthermia; treatment; improves survival ... See more keywords
VA-ECMO improves survival in cardiogenic shock
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-020-00450-y
Abstract: In the HAUSER randomized, placebo controlled clinical trial, paediatric patients (aged 10–17 years) with heterozygous familial hypercholesterolaemia treated with evolocumab (a fully human monoclonal antibody against PCSK9) for 24 weeks had a 44.5% mean reduction… read more here.
Keywords: reduction; group; improves survival; cardiogenic shock ... See more keywords
Adjuvant nivolumab improves survival after radical cystectomy
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Urology"
DOI: 10.1038/s41585-021-00493-x
Abstract: A phase III randomized, controlled trial has investigated the role of adjuvant treatment in high-risk muscle-invasive urothelial carcinoma after radical surgery. Patients with muscleinvasive cancer who had undergone radical cystectomy received nivolumab (240 mg intravenously;… read more here.
Keywords: group; improves survival; adjuvant nivolumab; radical cystectomy ... See more keywords
An ALPHA7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C2C12 Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Burned Mice
Sign Up to like & getrecommendations! Published in 2017 at "SHOCK"
DOI: 10.1097/shk.0000000000000849
Abstract: ABSTRACT The role of interleukin-6 (IL-6) in physiological processes and disease is poorly understood. The hypothesis tested in this study was that selective alpha7 acetylcholine receptor (&agr;7AChR) agonist, GTS-21, releases IL-6 in association with myonuclear… read more here.
Keywords: myonuclear accretion; improves survival; il6ko mice; mice ... See more keywords
Targeting aging cells improves survival
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abi4474
Abstract: Drugs that remove senescent cells cut coronavirus deaths in old mice Older age is associated with increased COVID-19 severity and mortality (1). Whether this is due to preexisting age-related health conditions or aging per se… read more here.
Keywords: targeting aging; infection; cells improves; improves survival ... See more keywords
ZLN005 improves the survival of polymicrobial sepsis by increasing the bacterial killing via inducing lysosomal acidification and biogenesis in phagocytes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1089905
Abstract: Polymicrobial sepsis still has a high mortality rate despite the development of antimicrobial agents, elaborate strategies to protect major organs, and the investment of numerous medical resources. Mitochondrial dysfunction, which acts as the center of… read more here.
Keywords: sepsis; zln005 improves; improves survival; sepsis increasing ... See more keywords