Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial Pharmacophore
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DOI: 10.3390/ph15080998
Abstract: An antileishmanial structure–activity relationship (SAR) study focused on positions 2 and 8 of the imidazo[1,2-a]pyridine ring was conducted through the synthesis of 22 new derivatives. After being screened on the promatigote and axenic amastigote stages… read more here.
Keywords: solubility vitro; pharmacokinetic properties; vitro pharmacokinetic; aqueous solubility ... See more keywords