Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness.
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DOI: 10.1182/blood.2022016112
Abstract: Hematopoietic stem cells (HSCs) have reduced capacities to properly maintain and replenish the hematopoietic system during myelosuppressive injury or aging. Expanding and rejuvenating HSCs for therapeutic purposes has been a long-sought goal, with limited progress.… read more here.
Keywords: hscs; sphingosine kinase; hematopoietic stem; improving metabolic ... See more keywords