The comparative study of cocrystal/salt in simultaneously improving solubility and permeability of acetazolamide
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.01.090
Abstract: Abstract With the purpose of improving solubility and permeability of acetazolamide (ACZ), two new solid forms including one salt with piperazine (PPZ), and one cocrystal with theophylline (THP), namely, ACZ-PPZ-H2O (1) and ACZ-THP (2), were… read more here.
Keywords: salt; solubility; permeability; permeability acetazolamide ... See more keywords
Improving the solubility, activity, and stability of reteplase using in silico design of new variants
Sign Up to like & getrecommendations! Published in 2019 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.263560
Abstract: Reteplase (recombinant plasminogen activator, r-PA) is a thrombolytic agent recombined from tissue-type plasminogen activator (t-PA), which has several prominent features such as strong thrombolytic ability and E. coli expressibility. Despite these outstanding features, it demonstrates… read more here.
Keywords: reteplase; solubility; stability; activity ... See more keywords