LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "impurity profiling" as a keyword



Impurity Profiling and Mechanistic Investigation of the Photochemical Degradation of Tetrandrine

Sign Up to like & get
recommendations! Published in 2025 at "Rapid Communications in Mass Spectrometry"

DOI: 10.1002/rcm.10102

Abstract: Tetrandrine is a bisbenzylisoquinoline alkaloid with diverse pharmacological activities and faces critical pharmaceutical challenges due to its inherent photolability under environmental stressors. Despite its therapeutic potential, systematic investigations into its photodegradation mechanisms and impurity profiling… read more here.

Keywords: impurity profiling; photochemical degradation; mechanistic investigation; profiling mechanistic ... See more keywords

Synthesis and organic impurity profiling of 4-methoxymethamphetamine hydrochloride and its precursors.

Sign Up to like & get
recommendations! Published in 2017 at "Forensic science international"

DOI: 10.1016/j.forsciint.2016.11.041

Abstract: 4-Methoxymethamphetamine (PMMA) was synthesised from star anise and from 4-methoxytoluene and the organic impurity profiles examined. These two starting materials are unrestricted chemicals in many jurisdictions and contain the requisite functional groups and are thus… read more here.

Keywords: organic impurity; methoxymethamphetamine hydrochloride; impurity profiling; synthesis organic ... See more keywords

Green HPTLC-densitometric approach for simultaneous determination and impurity- profiling of ebastine and phenylephrine hydrochloride

Sign Up to like & get
recommendations! Published in 2019 at "Microchemical Journal"

DOI: 10.1016/j.microc.2019.04.043

Abstract: Abstract Although analytical HPLC-technique can be considered as a well-accepted versatile approach for the drugs' separation, quantification, as well as impurity profiling, its regular adoption shows increasing environmental concerns provoked by high energy-consumption, instrument and… read more here.

Keywords: hptlc; phenylephrine hydrochloride; approach; impurity profiling ... See more keywords

Ion-Pairing Hydrophilic Interaction Chromatography for Impurity Profiling of Therapeutic Phosphorothioated Oligonucleotides

Sign Up to like & get
recommendations! Published in 2025 at "Analytical Chemistry"

DOI: 10.1021/acs.analchem.5c01407

Abstract: Therapeutic oligonucleotides (ONs) may contain many closely related impurities. Using conventional liquid chromatography (LC) modes, the separation of impurities comprising the same number of nucleotides as the ON product remains a challenge. In this study,… read more here.

Keywords: impurity profiling; pairing hydrophilic; ion pairing; impurity ... See more keywords

Development of Impurity Profiling Methods Using Modern Analytical Techniques

Sign Up to like & get
recommendations! Published in 2017 at "Critical Reviews in Analytical Chemistry"

DOI: 10.1080/10408347.2016.1169913

Abstract: ABSTRACT This review gives a brief introduction about the process- and product-related impurities and emphasizes on the development of novel analytical methods for their determination. It describes the application of modern analytical techniques, particularly the… read more here.

Keywords: development impurity; development; modern analytical; impurity profiling ... See more keywords

Quinquennial Review of Progress in Degradation Studies and Impurity Profiling: An Instrumental Perspective Statistics

Sign Up to like & get
recommendations! Published in 2019 at "Critical Reviews in Analytical Chemistry"

DOI: 10.1080/10408347.2019.1615863

Abstract: Abstract Degradation studies of drug give insightful information about the intrinsic stability of the molecule, the possible degradents formed during shelf life and thus, aid in the subsequent development of its stable formulation. For identification… read more here.

Keywords: degradation; quinquennial review; review progress; degradation studies ... See more keywords

Impurity profiling of amphetamine and methamphetamine using Gas Chromatography Mass Spectrometry (GCMS) harmonised methods

Sign Up to like & get
recommendations! Published in 2017 at "Sains Malaysiana"

DOI: 10.17576/jsm-2017-4601-19

Abstract: Impurity profiling of drug seizures is a scientific approach employed to understand drug trafficking networks thus has becoming increasingly important in criminal investigation. This paper presents the feasibility of using the Collaborative Harmonisation of Methods… read more here.

Keywords: gas chromatography; methamphetamine; profiling amphetamine; amphetamine methamphetamine ... See more keywords

Analytical Performance and Greenness Evaluation of Five Multi-Level Design Models Utilized for Impurity Profiling of Favipiravir, a Promising COVID-19 Antiviral Drug

Sign Up to like & get
recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27123658

Abstract: In 2018, the discovery of carcinogenic nitrosamine process related impurities (PRIs) in a group of widely used drugs led to the recall and complete withdrawal of several medications that were consumed for a long time,… read more here.

Keywords: impurity profiling; level design; multi level; level ... See more keywords