TRPV1 mediates inflammation and hyperplasia in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2018.11.009
Abstract: BACKGROUND Transient Receptor Potential Vanilloid 1 (TRPV1) is known to mediate itch and neurogenic inflammation, but the role of TRPV1 in psoriasiform dermal inflammation is poorly understood. OBJECTIVE To investigate the function of TRPV1 in… read more here.
Keywords: trpv1; psoriasiform; imq; inflammation ... See more keywords
In vitro anti-melanoma activity of imiquimod in ultradeformable nanovesicles
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2022.2153861
Abstract: Abstract Background The wide spectrum of antitumoral mechanisms of imiquimod (IMQ), made it a good candidate for topical therapy of melanoma. However, physicochemical properties make IMQ formulation a difficult task. Solubility and skin penetration of… read more here.
Keywords: melanoma; udl imq; ultradeformable nanovesicles; uda imq ... See more keywords
Probiotic Lactobacillus sakei proBio-65 Extract Ameliorates the Severity of Imiquimod Induced Psoriasis-Like Skin Inflammation in a Mouse Model
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.01021
Abstract: This study was designed to evaluate the protective effect of ethanol extract (SEL001) isolated from a potent probiotic strain Lactobacillus sakei proBio-65 on imiquimod (IMQ)-induced psoriasis-like skin inflammation in a mouse model. Histopathological and histomorphometrical… read more here.
Keywords: treated groups; induced psoriasis; imq; lactobacillus sakei ... See more keywords
Psoriasiform Inflammation Is Associated with Mitochondrial Fission/GDAP1L1 Signaling in Macrophages
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DOI: 10.3390/ijms221910410
Abstract: While psoriasis is known as a T cell- and dendritic cell-driven skin inflammation disease, macrophages are also reported to play some roles in its development. However, the signaling pathway of activated macrophages contributing to psoriasis… read more here.
Keywords: imq; inflammation; gdap1l1; mitochondrial fission ... See more keywords
Phospholipid-Based Microemulsions for Cutaneous Imiquimod Delivery
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DOI: 10.3390/ph15050515
Abstract: Imiquimod (IMQ) is a potent immune response modifier with antiviral and antitumor properties. IMQ’s low aqueous solubility and unsatisfactory cutaneous permeability limit its formulation into effective dosage forms. This work aimed to develop IMQ-loaded microemulsions… read more here.
Keywords: cutaneous imiquimod; phospholipid based; imq; microemulsions cutaneous ... See more keywords
Transcutaneous Administration of Imiquimod Promotes T and B Cell Differentiation into Effector Cells or Plasma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020385
Abstract: We are interested in promoting the development of transcutaneous immunization using microneedle technology and attempting to apply an adjuvant with transcutaneous immunization to improve the efficacy and reduce the amount of antigen and number of… read more here.
Keywords: group; cell differentiation; imq; administration ... See more keywords