Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2020.03.009
Abstract: BACKGROUND Mitochondrial homeostasis is a highly dynamic process involving continuous fission and fusion cycles and mitophagy to maintain mitochondrial functionality. Imiquimod (IMQ), a Toll-like receptor (TLR) 7 ligand, is used to treat various skin malignancies.… read more here.
Keywords: ros production; skin cancer; induced ros; cancer cells ... See more keywords
Phosphatidylserine Topically Attenuates Imiquimod-induced Psoriasis Through Inflammation Inhibition in Mice
Sign Up to like & getrecommendations! Published in 2024 at "Drug Research"
DOI: 10.1055/a-2419-9616
Abstract: Abstract Background Psoriasis is a chronic skin condition that is associated with persistent inflammation and skin lesions. Topical therapy has been a promising approach to the alleviation of psoriasis through the application of anti-inflammatory agents.… read more here.
Keywords: induced psoriasis; imq induced; inhibition; pasi score ... See more keywords
P093/O16 IL-36 signaling in keratinocytes is mandatory in imiquimod-induced psoriasis in mice
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-ewrr2019.82
Abstract: Career situation of first and presenting author Post-doctoral fellow. Introduction A large body of evidence indicates that IL-36R signaling plays an important role in the pathogenesis of psoriasis. For instance, IL-36 receptor (IL-36R)-deficient mice showed… read more here.
Keywords: 36r mice; mice; psoriasis; signaling keratinocytes ... See more keywords
L-Theanine Alleviates IMQ-Induced Psoriasis Like Skin Inflammation by Downregulating the Production of IL-23 and Chemokines
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.719842
Abstract: Psoriasis, the most common skin inflammatory disease, is characterized by massive keratinocyte proliferation and immune cell infiltration into epidermis. L-Theanine (L-THE), a nonproteinogenic amino acid derived from green tea (Camellia sinensis), has been proved to… read more here.
Keywords: induced psoriasis; imq induced; inflammation; psoriasis ... See more keywords
Aloperine Ameliorates IMQ-Induced Psoriasis by Attenuating Th17 Differentiation and Facilitating Their Conversion to Treg
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.778755
Abstract: Aloperine is an anti-inflammatory compound isolated from the Chinese herb Sophora alopecuroides L. Previously, our group has reported that the generation of induced Treg was promoted by aloperine treatment in a mouse colitis model. However,… read more here.
Keywords: imq induced; th17 differentiation; induced psoriasis; differentiation ... See more keywords
Myricetin Attenuates IMQ-Induced Psoriatic Inflammation Through Multi-Target Modulation: Evidence from Network Pharmacology and Experimental Validation
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceuticals"
DOI: 10.3390/ph18121802
Abstract: Background: Psoriasis is a chronic inflammatory skin disease driven by keratinocyte hyperproliferation and immune dysregulation. Despite the availability of biologics and immunosuppressants, recurrence and adverse effects remain major limitations. Myricetin (Myr), a natural flavonoid with… read more here.
Keywords: induced psoriatic; imq induced; network pharmacology; pharmacology ... See more keywords
Heparanase Contributes to Psoriatic Lesions Through Crosstalk with IL-17 Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Indian Journal of Dermatology"
DOI: 10.4103/ijd.ijd_641_22
Abstract: Psoriasis is a chronic inflammatory disease that is considered by a network of immunocytes and cytokines. Among all, Th17 cells–derived IL-17 is a critical driving factor in the pathogenesis of psoriasis. Recently, disruption of the… read more here.
Keywords: imq induced; th17 cells; hpse; induced psoriasis ... See more keywords