Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform
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DOI: 10.1038/s41467-024-47795-3
Abstract: Genetic interactions mediate the emergence of phenotype from genotype, but technologies for combinatorial genetic perturbation in mammalian cells are challenging to scale. Here, we identify background-independent paralog synthetic lethals from previous CRISPR genetic interaction screens,… read more here.
Keywords: genetic interaction; platform; cas12a; in4mer crispr ... See more keywords