Late sodium current and calcium homeostasis in arrhythmogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Channels"
DOI: 10.1080/19336950.2020.1854986
Abstract: ABSTRACT The cardiac late sodium current (INa,late) is the small sustained component of the sodium current active during the plateau phase of the action potential. Several studies demonstrated that augmentation of the current can lead… read more here.
Keywords: ina late; homeostasis; late sodium; sodium current ... See more keywords
Experimental hypothyroidism induces cardiac arrhythmias and ranolazine reverts and prevents the phenotype.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.2139/ssrn.4179111
Abstract: AIMS Hypothyroidism is associated with an increased risk of cardiovascular disease and enhanced susceptibility to arrhythmias. In our investigation, we evaluated the potential involvement of late sodium current (INa,late) in cardiac arrhythmias in an experimental… read more here.
Keywords: arrhythmias ranolazine; ina late; cardiac arrhythmias; experimental hypothyroidism ... See more keywords
Gender Difference in Lithium-Induced Sodium Current Dysregulation and Ventricular Arrhythmogenesis in Right Ventricular Outflow Tract Cardiomyocytes
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DOI: 10.3390/biomedicines10112727
Abstract: Lithium intoxication induces Brugada-pattern ECG, ventricular arrhythmia, and sudden death with the predominant preference for the male over the female gender. This study investigated the mechanisms of gender difference in lithium-induced arrhythmogenesis. The ECG parameters… read more here.
Keywords: ina late; ina; lithium; brugada pattern ... See more keywords
Delayed Ventricular Repolarization and Sodium Channel Current Modification in a Mouse Model of Rett Syndrome
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DOI: 10.3390/ijms23105735
Abstract: Rett syndrome (RTT) is a severe developmental disorder that is strongly linked to mutations in the MECP2 gene. RTT has been associated with sudden unexplained death and ECG QT interval prolongation. There are mixed reports… read more here.
Keywords: prolongation; rett syndrome; ina late; ina ... See more keywords
Conductance Changes of Na+ Channels during the Late Na+ Current Flowing under Action Potential Voltage Clamp Conditions in Canine, Rabbit, and Guinea Pig Ventricular Myocytes
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DOI: 10.3390/ph16040560
Abstract: Late sodium current (INa,late) is an important inward current contributing to the plateau phase of the action potential (AP) in the mammalian heart. Although INa,late is considered as a possible target for antiarrhythmic agents, several… read more here.
Keywords: guinea pig; gna late; ina late; rabbit ... See more keywords