Expanding role of ribosome‐inactivating proteins: From toxins to therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2675
Abstract: Ribosome‐inactivating proteins (RIPs) are toxic proteins with N‐glycosidase activity. RIPs exert their action by removing a specific purine from 28S rRNA, thereby, irreversibly inhibiting the process of protein synthesis. RIPs can target both prokaryotic and… read more here.
Keywords: ribosome inactivating; expanding role; inactivating proteins; role ribosome ... See more keywords
Transcriptional Network Inference and Master Regulator Analysis of the Response to Ribosome-Inactivating Proteins in Leukemia Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology"
DOI: 10.1016/j.tox.2020.152531
Abstract: Gene-regulatory networks reconstruction has become a very popular approach in applied biology to infer and dissect functional interactions of Transcription Factors (TFs) driving a defined phenotypic state, termed as Master Regulators (MRs). In the present… read more here.
Keywords: master; response; leukemia cells; analysis ... See more keywords
Isolation, Characterization and Biological Action of Type-1 Ribosome-Inactivating Proteins from Tissues of Salsola soda L.
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14080566
Abstract: Ribosome-inactivating proteins (RIPs) are known as RNA N-glycosylases. They depurinate the major rRNA, damaging ribosomes and inhibiting protein synthesis. Here, new single-chain (type-1) RIPs named sodins were isolated from the seeds (five proteins), edible leaves… read more here.
Keywords: salsola soda; type; ribosome inactivating; inactivating proteins ... See more keywords