The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation
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DOI: 10.1002/2211-5463.12273
Abstract: Voltage‐dependent inactivation of ion channels contributes to the regulation of the membrane potential of excitable cells. Mouse polycystic kidney disease 2‐like 1 (PKD2L1) forms voltage‐dependent nonselective cation channels, which are activated but subsequently inactivated in… read more here.
Keywords: pore loop; pkd2l1; outer pore; inactivation ... See more keywords
Highly Efficient and Rapid Inactivation of Coronavirus on Non‐Metal Hydrophobic Laser‐Induced Graphene in Mild Conditions
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DOI: 10.1002/adfm.202101195
Abstract: Abstract The prevalence of COVID‐19 has caused global dysfunction in terms of public health, sustainability, and socio‐economy. While vaccination shows potential in containing the spread, the development of surfaces that effectively reduces virus transmission and… read more here.
Keywords: metal; inactivation; efficient rapid; induced graphene ... See more keywords
Multivalent Nanosheet Antibody Mimics for Selective Microbial Recognition and Inactivation.
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DOI: 10.1002/adma.202101376
Abstract: Antibodies are widely used as recognition elements in sensing and therapy, but they suffer from poor stability, long discovery time, and high cost. Herein, a facile approach to create antibody mimics with flexible recognition phases… read more here.
Keywords: tpa antibody; pathogenic bacteria; recognition; inactivation ... See more keywords
Causality in transcription and genome folding: Insights from X inactivation
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DOI: 10.1002/bies.202200105
Abstract: The spatial organization of genomes is becoming increasingly understood. In mammals, where it is most investigated, this organization ties in with transcription, so an important research objective is to understand whether gene activity is a… read more here.
Keywords: genome folding; transcription genome; inactivation; causality transcription ... See more keywords
Physiochemical properties of enveloped viruses and arginine dictate inactivation
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DOI: 10.1002/biot.202000342
Abstract: Therapeutic protein manufacturing would benefit by having an arsenal of ways to inactivate viruses. There have been many publications on the virus inactivation ability of arginine at pH 4.0, but the mechanism of this inactivation… read more here.
Keywords: virus inactivation; enveloped viruses; properties enveloped; physiochemical properties ... See more keywords
Revisiting mouse minute virus inactivation by high temperature short time treatment
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DOI: 10.1002/bit.27805
Abstract: In recent years, high temperature short time (HTST) treatment technology has been increasingly adopted for medium treatment to mitigate the potential risk of viral contamination in mammalian cell culture GMP manufacturing facilities. Mouse minute virus… read more here.
Keywords: medium; treatment; mmv; time ... See more keywords
Modeling bioaffinity-based targeted delivery of antimicrobials to Escherichia coli biofilms using yeast microparticles. Part II: parameter evaluation and validation.
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DOI: 10.1002/bit.27969
Abstract: The design of bioaffinity-based targeted delivery systems for biofilm inactivation may require a comprehensive understanding of physicochemical and biochemical properties of biobased antimicrobial particles and their interactions with biofilm. In this study, Escherichia coli biofilm… read more here.
Keywords: inactivation; bioaffinity based; targeted delivery; yeast microparticles ... See more keywords
Continuous low pH viral inactivation: Operation and scaling strategy informs viral clearance study
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DOI: 10.1002/bit.28117
Abstract: A continuous viral inactivation (CVI) tubular reactor was designed for low pH viral inactivation within a continuous downstream system across multiple scales of operation. The reactors were designed to provide a minimum residence time of… read more here.
Keywords: operation; inactivation operation; low viral; viral inactivation ... See more keywords
Ethanol addition on inactivation of Saccharomyces pastorianus by a two‐stage system with low‐pressure carbon dioxide microbubbles can accelerate the cell membrane injury
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DOI: 10.1002/btpr.2579
Abstract: The effect of ethanol on the inactivation of Saccharomyces pastorianus by a two‐stage system with low‐pressure carbon dioxide microbubbles (two‐stage MBCO2) was investigated. Zero and >5 log reductions of S. pastorianus populations suspended in physiological… read more here.
Keywords: two stage; stage mbco2; containing ethanol; inactivation ... See more keywords
Arginine‐enveloped virus inactivation and potential mechanisms
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DOI: 10.1002/btpr.2931
Abstract: Arginine synergistically inactivates enveloped viruses at a pH or temperature that does little harm to proteins, making it a desired process for therapeutic protein manufacturing. However, the mechanisms and optimal conditions for inactivation are not… read more here.
Keywords: enveloped viruses; viral inactivation; arginine; inactivation ... See more keywords
Synthesis of Photosensitizers Based on Tetrapyrrolic Macrocycles for Combination with Antibiotics: Dual Inactivation of Bacteria.
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DOI: 10.1002/cplu.202200228
Abstract: The combination of photodynamic therapy with antibiotics or antimicrobial peptides for inactivation of bacteria is an area of growing interest due to the synergistic effect already observed by many authors. It has been shown that… read more here.
Keywords: inactivation bacteria; combination; dual inactivation; tetrapyrrolic macrocycles ... See more keywords