Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression.
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DOI: 10.1158/0008-5472.can-17-2320
Abstract: Resident fibroblasts that contact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts (CAF) that stimulate oncogenic signaling in TEC. In this study, we evaluated the cross-talk between CAF and TEC isolated from tumors… read more here.
Keywords: associated fibroblasts; pancreatic cancer; oncogenic signaling; cancer ... See more keywords