A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
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DOI: 10.7554/elife.82281
Abstract: Ca2+ release-activated Ca2+ (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca2+ sensor. A hallmark of CRAC channels is fast Ca2+-dependent inactivation (CDI) which provides… read more here.
Keywords: orai1; human orai1; inactivation orai1; cdi ... See more keywords