Conformational states dynamically populated by a kinase determine its function
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DOI: 10.1126/science.abc2754
Abstract: A moving target Abl kinase is an important signaling protein that is dysregulated in leukemia and other cancers and is the target of inhibitors such as imatinib. Like other kinases, Abl kinase is dynamic, and… read more here.
Keywords: inactive states; abl kinase; kinase; conformational states ... See more keywords