Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research
Sign Up to like & getrecommendations! Published in 2018 at "Mammalian Genome"
DOI: 10.1007/s00335-018-9751-x
Abstract: Inbred mouse strains derived from the species Mus spretus have been very informative in the study of certain gene polymorphisms in inflammation and infection. Based on our interest in sepsis, we used SPRET/EiJ mice and… read more here.
Keywords: inflammation infection; inflammation; spret eij; inbred mouse ... See more keywords
Whole-Genome Sequencing of Inbred Mouse Strains Selected for High and Low Open-Field Activity
Sign Up to like & getrecommendations! Published in 2020 at "Behavior Genetics"
DOI: 10.1007/s10519-020-10014-y
Abstract: We conducted whole-genome sequencing of four inbred mouse strains initially selected for high (H1, H2) or low (L1, L2) open-field activity (OFA), and then examined strain distribution patterns for all DNA variants that differed between… read more here.
Keywords: whole genome; high low; mouse strains; inbred mouse ... See more keywords
Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation
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DOI: 10.1093/nsr/nwaa285
Abstract: Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation Feng-Liang Liu1,†, Kaixin Wu2,3,7,8,†, Jiaoyang Sun3,4,6,†, Zilei Duan1,†, Xiongzhi Quan2,3, Junqi Kuang2,3,4, Shilong Chu2,3, Wei Pang2,3, Han Gao2, Ling Xu1, Ying-Chang Li1,… read more here.
Keywords: ace2 humanized; generation ace2; inbred mouse; humanized inbred ... See more keywords
Regulation of posterior Hox genes by sex steroids explains vertebral variation in inbred mouse strains.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of anatomy"
DOI: 10.1111/joa.13580
Abstract: A series of elegant embryo transfer experiments in the 1950s demonstrated that the uterine environment could alter vertebral patterning in inbred mouse strains. In the intervening decades, attention has tended to focus on the technical… read more here.
Keywords: hox genes; genes sex; sex steroids; sex ... See more keywords
Novel Neuroprotective Loci Modulating Ischemic Stroke Volume in Wild-Derived Inbred Mouse Strains.
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302555
Abstract: To identify genes involved in cerebral infarction, we have employed a forward genetic approach in inbred mouse strains, using quantitative trait loci (QTL) mapping for cerebral infarct volume after middle cerebral artery occlusion. We had… read more here.
Keywords: volume; eij; wild derived; mouse strains ... See more keywords
How Our Continuing Studies of the Pre-clinical Inbred Mouse Models of Mesothelioma Have Influenced the Development of New Therapies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.858557
Abstract: Asbestos-induced preclinical mouse models of mesothelioma produce tumors that are very similar to those that develop in humans and thus represent an ideal platform to study this rare, universally fatal tumor type. Our team and… read more here.
Keywords: mouse; models mesothelioma; studies pre; inbred mouse ... See more keywords
In silico candidate variant and gene identification using inbred mouse strains
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DOI: 10.7717/peerj.11017
Abstract: Mice are the most widely used animal model to study genotype to phenotype relationships. Inbred mice are genetically identical, which eliminates genetic heterogeneity and makes them particularly useful for genetic studies. Many different strains have… read more here.
Keywords: candidate variant; candidate; mouse strains; inbred mouse ... See more keywords