Identification of a First-in-Class SETD2 Inhibitor That Shows Potent and Selective Anti-Proliferative Activity in t(4;14) Multiple Myeloma: T(4;14) Multiple Myeloma Cells Are Dependent on Both H3K36 Di and Tri-Methylation
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DOI: 10.1182/blood-2018-99-110803
Abstract: t(4;14) chromosome translocations are found in 15% of newly diagnosed multiple myeloma (MM) cases and are associated with high risk. MM cells with t(4;14) over-express the histone methyltransferase (HMT), WHSC1/MMSET/NSD2, which leads to deregulation of… read more here.
Keywords: epizyme inc; equity ownership; inc employment; employment equity ... See more keywords
Pozelimab, a Human Antibody Against Complement Factor C5, Demonstrates Robust Inhibition of Alternative Complement Activity Both in Normal Human Serum and in Phase I Normal Healthy Volunteers
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DOI: 10.1182/blood-2019-129865
Abstract: INTRODUCTION: Blockade of complement factor C5 has demonstrated benefit in paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, generalized myasthenia gravis and neuromyelitis optica. We have completed a Phase I study of pozelimab, a fully human… read more here.
Keywords: regeneron pharmaceuticals; hemolysis; employment equity; pharmaceuticals inc ... See more keywords
Loss of Heterozygosity of FLT3-ITD Is Common in Acute Myeloid Leukemia and May be a More Consistent Prognostic Marker Than FLT3-ITD Allele Frequency
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DOI: 10.1182/blood-2019-131248
Abstract: BACKGROUND: FLT3 alterations in Acute Myeloid Leukemia (AML) occur as either point mutations in the tyrosine kinase domain (TKD) or internal tandem duplications (ITD), both of which result in constitutive activation of FLT3; however, only… read more here.
Keywords: medicine; flt3; inc employment; flt3 itd ... See more keywords
Preclinical Characterization of AMG 424, a Novel Humanized T Cell-Recruiting Bispecific Anti-CD3/CD38 Antibody
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DOI: 10.1182/blood.v130.suppl_1.500.500
Abstract: Introduction: Multiple myeloma (MM) is a highly prevalent hematological malignancy, with a worldwide incidence of over 62,000 patients in 2012. Despite significant progress in the development of MM treatments in the last decade, there is… read more here.
Keywords: employment; amg 424; inc employment; equity ownership ... See more keywords
Reawakening of Human Fetal Hemoglobin and an Epigenetic Path to the Clinic for Sickle Cell Disease and Beta-Thalassemia: Identification of an Orally-Available, Potent, and Selective Euchromatic Histone Lysine Methyltransferase 1 and 2 (EHMT1/2) Inhibitor
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DOI: 10.1182/blood.v130.suppl_1.537.537
Abstract: Expression of genes in the β-globin locus switch via epigenetic control at key stages of early gestational development from an embryonic (HbE, α2e2) to fetal form (HbF, α2γ2) and again around birth to the adult… read more here.
Keywords: epizyme inc; equity ownership; inc employment; employment equity ... See more keywords