Metabolome and transcriptome analysis on muscle of sporadic inclusion body myositis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51657
Abstract: Sporadic inclusion body myositis (sIBM) is the most common acquired myopathy in patients older than 50 years of age. sIBM is hardly responds to any immunosuppressing theraphies, and its pathophysiology remains elusive. This study aims to… read more here.
Keywords: inclusion body; sporadic inclusion; body myositis; metabolome transcriptome ... See more keywords
Pathomechanisms of anti–cytosolic 5′‐nucleotidase 1A autoantibodies in sporadic inclusion body myositis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Neurology"
DOI: 10.1002/ana.24919
Abstract: Sporadic inclusion body myositis (sIBM), an intractable progressive muscle disease, frequently occurs in older persons. sIBM pathogenesis may involve protein degradation dysfunction and immune abnormalities. Autoantibodies recognizing cytosolic 5′‐nucleotidase 1A (cN1A) were found in plasma… read more here.
Keywords: body myositis; cytosolic nucleotidase; sporadic inclusion; inclusion body ... See more keywords
Unravelling inclusion body myositis using a patient‐derived fibroblast model
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13178
Abstract: Inclusion body myositis (IBM) is an inflammatory myopathy clinically characterized by proximal and distal muscle weakness, with inflammatory infiltrates, rimmed vacuoles and mitochondrial changes in muscle histopathology. There is scarce knowledge on IBM aetiology, and… read more here.
Keywords: inclusion body; body myositis; unravelling inclusion;
Immunohistochemical and ultrastructural analysis of sporadic inclusion body myositis: a case series
Sign Up to like & getrecommendations! Published in 2018 at "Rheumatology International"
DOI: 10.1007/s00296-018-4221-z
Abstract: Sporadic inclusion body myositis (s-IBM) is a progressive, skeletal muscle disease with poor prognosis. However, establishing the final diagnosis is difficult because of the lack of clear biomarkers in the blood serum and very slow… read more here.
Keywords: sporadic inclusion; microscopy; immunohistochemical ultrastructural; rheumatology ... See more keywords
The impact of technical failures during cultivation of an inclusion body process
Sign Up to like & getrecommendations! Published in 2019 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-019-02158-x
Abstract: In biotechnological processes, technical failures in the upstream process often lead to batch loss. It is of great interest to investigate the empirical impact of technical failures to understand and mitigate their impact accurately and… read more here.
Keywords: process; inclusion body; technical failures; impact technical ... See more keywords
Efficient renaturation of inclusion body proteins denatured by SDS.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.003
Abstract: Inclusion bodies are often formed when the foreign protein is over expressed in Escherichia coli. Since proteins in inclusion bodies are inactive, denaturing and refolding of inclusion body proteins are necessary to obtain the active… read more here.
Keywords: inclusion bodies; inclusion; body proteins; sds ... See more keywords
Effect of intravenous immunoglobulin therapy on anti-NT5C1A antibody-positive inclusion body myositis after successful treatment of hepatitis C: A case report
Sign Up to like & getrecommendations! Published in 2019 at "eNeurologicalSci"
DOI: 10.1016/j.ensci.2019.100204
Abstract: Inclusion body myositis (IBM) is the commonest idiopathic inflammatory myopathy of older persons. Pathophysiological mechanism of IBM remains unknown; however, an association of IBM with chronic hepatitis C virus (HCV) infection and serum autoantibodies against… read more here.
Keywords: hepatitis; treatment; therapy; inclusion body ... See more keywords
Clinical and pathological features in patients with Nakajo-Nishimura syndrome and inclusion body myositis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2017.08.2306
Abstract: disease characterized by remittent fever, skin rash, emaciation of the face and upper body, and long gnarled fingers with contractures. Mutation of the gene encoding the β5i subunit of the immunoproteasome causes the accumulation of… read more here.
Keywords: pathological features; clinical pathological; body myositis; inclusion body ... See more keywords
Acquired equine polyneuropathy of Nordic horses: A conspicuous inclusion body schwannopathy
Sign Up to like & getrecommendations! Published in 2017 at "Neuromuscular Disorders"
DOI: 10.1016/j.nmd.2017.06.005
Abstract: Acquired equine polyneuropathy (AEP), formerly also known as Scandinavian knuckling syndrome, is one of the most prevalent polyneuropathies in equids in Norway and Sweden, with more than 400 cases registered since first observations in 1995.… read more here.
Keywords: body schwannopathy; inclusion body; acquired equine; equine polyneuropathy ... See more keywords
Mitochondrial DNA depletion in sporadic inclusion body myositis
Sign Up to like & getrecommendations! Published in 2019 at "Neuromuscular Disorders"
DOI: 10.1016/j.nmd.2019.02.001
Abstract: Sporadic inclusion body myositis (sIBM) is a late onset disorder of unkown aetiology. Mitochondrial changes such as cytochrome oxidase deficient fibres are a well recognised feature and mitochondrial DNA (mtDNA) deletions have also been reported,… read more here.
Keywords: sporadic inclusion; mtdna; body myositis; mitochondrial dna ... See more keywords
Exploring the efficacy of the expiratory muscle strength trainer to improve swallowing in inclusion body myositis: A pilot study
Sign Up to like & getrecommendations! Published in 2020 at "Neuromuscular Disorders"
DOI: 10.1016/j.nmd.2020.02.010
Abstract: Inclusion Body Myositis (IBM) is the most common acquired myopathy in older individuals with more than two thirds of patients experiencing impaired swallowing. There are currently no standardized exercise therapies to improve or sustain swallowing… read more here.
Keywords: muscle strength; expiratory muscle; pilot study; pilot ... See more keywords