α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration
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DOI: 10.1016/j.nbd.2017.05.014
Abstract: Proteinaceous inclusions in neurons, composed primarily of α-synuclein, define the pathology in several neurodegenerative disorders. Neurons can internalize α-synuclein fibrils that can seed new inclusions from endogenously expressed α-synuclein. The factors contributing to the spread… read more here.
Keywords: inclusion spread; dopaminergic neurodegeneration; spread; pathology ... See more keywords