Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24493
Abstract: Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock‐in HD mouse models were generated such that HdhQ150 mice have an… read more here.
Keywords: knock; htt; splicing mutant; mice ... See more keywords