Incorporating networks in a probabilistic graphical model to find drivers for complex human diseases
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DOI: 10.1371/journal.pcbi.1005580
Abstract: Discovering genetic mechanisms driving complex diseases is a hard problem. Existing methods often lack power to identify the set of responsible genes. Protein-protein interaction networks have been shown to boost power when detecting gene-disease associations.… read more here.
Keywords: incorporating networks; graphical model; conflux; gene ... See more keywords