Using chemical chaperones to increase recombinant human erythropoietin secretion in CHO cell line
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DOI: 10.1080/10826068.2018.1479865
Abstract: Abstract In recombinant protein production, over-expressed genes induce unfolded protein response (UPR), overloaded protein aggregation in endoplasmic reticulum and its expansion. In this study, we have used 16 chemicals to improve erythropoietin production in engineered… read more here.
Keywords: erythropoietin; secretion; endoplasmic reticulum; expansion ... See more keywords