Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-06-0393
Abstract: Tissue profiles and MSC transcriptomics separately indicate that LBR varies inversely with lamin-A,C. Such anti-correlations are recapitulated in MSC adipogenesis and osteogenesis as well as with matrix elasticity, knockdowns, overexpression, and myosin-II inhibition, which together… read more here.
Keywords: nuclear tension; increase nuclear; tension lamin; tissue ... See more keywords
Irradiation-induced increase in nuclear p62 levels contributes to chromosomal fragmentation and chromothripsis.
Sign Up to like & getrecommendations! Published in 2025 at "International journal of surgery"
DOI: 10.1097/js9.0000000000002643
Abstract: Chromosomal instability (CIN) is a hallmark of cancer, closely associated with tumor evolution, metastasis, immune evasion, and resistance to treatment. CIN is driven by persistent chromosome missegregation, resulting in abnormal chromosomal copy numbers and promoting… read more here.
Keywords: fragmentation chromothripsis; chromothripsis; nuclear p62; increase nuclear ... See more keywords