Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes
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DOI: 10.1091/mbc.e17-06-0393
Abstract: Tissue profiles and MSC transcriptomics separately indicate that LBR varies inversely with lamin-A,C. Such anti-correlations are recapitulated in MSC adipogenesis and osteogenesis as well as with matrix elasticity, knockdowns, overexpression, and myosin-II inhibition, which together… read more here.
Keywords: nuclear tension; increase nuclear; tension lamin; tissue ... See more keywords