HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA‐less cancer cells
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DOI: 10.1111/cas.15582
Abstract: Recent comprehensive analyses of mtDNA and orthogonal RNA‐sequencing data revealed that in numerous human cancers, mtDNA copy numbers and mtRNA amounts are significantly reduced, followed by low respiratory gene expression. Under such conditions (called mt‐Low),… read more here.
Keywords: cell proliferation; p27kip1; increase p27kip1; igfbp1 akt ... See more keywords