Increased activation ability of monocytes from ALS patients
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113259
Abstract: Neuroinflammation is increasingly recognized as an important mediator of disease progression in patients with amyotrophic lateral sclerosis (ALS). Recent research suggests that pro-inflammatory microglia in ALS mice promote motoneuron cytotoxicity by secreting reactive oxygen species… read more here.
Keywords: activation ability; monocytes als; disease progression; als patients ... See more keywords
Increased activation of cGAS-STING pathway enhances radiosensitivity of non-small cell lung cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Thoracic cancer"
DOI: 10.1111/1759-7714.14400
Abstract: BACKGROUND Radiotherapy is an effective therapeutic approach widely used clinically in non-small cell lung cancer (NSCLC), but radioresistance remains a major challenge. New and effective radiosensitizing approaches are thus urgently needed. The activation of DNA-sensing… read more here.
Keywords: sting pathway; cgas sting; activation cgas; increased activation ... See more keywords
Dermokine contributes to epithelial–mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Science"
DOI: 10.1111/cas.13347
Abstract: Dermokine (DMKN) was first identified in relation to skin lesion healing and skin carcinoma. Recently, its expression was associated with pancreatic cancer tumorigenesis, although its involvement remains poorly understood. Herein, we showed that DMKN loss… read more here.
Keywords: signal transducer; activator transcription; transducer activator; pancreatic cancer ... See more keywords
Engineered Removal of PD-1 From the Surface of CD19 CAR-T Cells Results in Increased Activation and Diminished Survival
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.745286
Abstract: CAR-T cell therapy is the most advanced way to treat therapy resistant hematologic cancers, in particular B cell lymphomas and leukemias, with high efficiency. Donor T cells equipped ex vivo with chimeric receptor recognize target… read more here.
Keywords: surface; car cells; car; increased activation ... See more keywords