Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis
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DOI: 10.1172/jci.insight.150723
Abstract: Aristolochic acid (AA) is the causative nephrotoxic alkaloid in AA nephropathy, which results in a tubulointerstitial fibrosis. AA causes direct proximal tubule damage as well as an influx of macrophages, although the role of macrophages… read more here.
Keywords: increased apoptosis; aristolochic acid; interferon regulatory; migration ... See more keywords
Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells
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DOI: 10.1371/journal.pone.0170470
Abstract: Myelodysplastic syndromes (MDS) are the most common adult myeloid blood cancers in the US. Patients have increased apoptosis in their bone marrow cells leading to low peripheral blood counts. The full complement of gene mutations… read more here.
Keywords: progenitor cells; apoptosis; increased apoptosis; knockdown hspa9 ... See more keywords