Increased Ca2+ influx through CaV1.2 drives aortic valve calcification
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.155569
Abstract: Calcific aortic valve disease (CAVD) is heritable, as revealed by recent GWAS. While polymorphisms linked to increased expression of CACNA1C — encoding the CaV1.2 L-type voltage-gated Ca2+ channel — and increased Ca2+ signaling are associated… read more here.
Keywords: cav1; increased ca2; ca2 influx; aortic valve ... See more keywords
Increased Ca2+ signaling in NRXN1α+/− neurons derived from ASD induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Autism"
DOI: 10.1186/s13229-019-0303-3
Abstract: BackgroundAutism spectrum disorder (ASD) is a neurodevelopmental disorder with a high co-morbidity of epilepsy and associated with hundreds of rare risk factors. NRXN1 deletion is among the commonest rare genetic factors shared by ASD, schizophrenia,… read more here.
Keywords: neurons derived; ca2 transients; increased ca2; derived asd ... See more keywords