Increased chromatin accessibility facilitates intron retention in specific cell differentiation states
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac994
Abstract: Abstract Dynamic intron retention (IR) in vertebrate cells is of widespread biological importance. Aberrant IR is associated with numerous human diseases including several cancers. Despite consistent reports demonstrating that intrinsic sequence features can help introns… read more here.
Keywords: chromatin accessibility; cell; increased chromatin; intron retention ... See more keywords
Increased chromatin accessibility promotes the evolution of a transcriptional silencer in Drosophila
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade6529
Abstract: The loss of discrete morphological traits, the most common evolutionary transition, is typically driven by changes in developmental gene expression. Mutations accumulating in regulatory elements of these genes can disrupt DNA binding sites for transcription… read more here.
Keywords: accessibility; drosophila; promotes evolution; increased chromatin ... See more keywords