Dapagliflozin attenuates arrhythmic vulnerabilities by regulating connexin43 expression via the AMPK pathway in post-infarcted rat hearts.
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DOI: 10.1016/j.bcp.2021.114674
Abstract: We have demonstrated that dapagliflozin, a sodium-glucose cotransporter (SGLT) 2 inhibitor, attenuates reactive oxygen species (ROS) production. Connexin43 playing a role in ventricular arrhythmia is sensitive to redox status. No data are available on the… read more here.
Keywords: increased connexin43; ros levels; phosphorylation; significantly increased ... See more keywords