Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis
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DOI: 10.1111/acel.13698
Abstract: It is known that chondrocytes from joints with osteoarthritis (OA) exhibit high levels of DNA damage, but the degree to which chondrocytes accumulate DNA damage during “normal aging” has not been established. The goal of… read more here.
Keywords: increased dna; damage; dna damage; comet assay ... See more keywords
Oxidative-Stress-Associated Proteostasis Disturbances and Increased DNA Damage in the Hippocampal Granule Cells of the Ts65Dn Model of Down Syndrome
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DOI: 10.3390/antiox11122438
Abstract: Oxidative stress (OS) is one of the neuropathological mechanisms responsible for the deficits in cognition and neuronal function in Down syndrome (DS). The Ts65Dn (TS) mouse replicates multiple DS phenotypes including hippocampal-dependent learning and memory… read more here.
Keywords: increased dna; hippocampal granule; damage; dna damage ... See more keywords