Curcumin‐mediated demethylation of the proximal promoter CpG island enhances the KLF4 recruitment that leads to increased expression of p21Cip1 in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27442
Abstract: Curcumin, the active component of the spice turmeric, induce global DNA hypomethylation as it has been shown to inhibit DNA methyltransferases. It promotes cell death in cancer cells by arresting in the G1 phase. It… read more here.
Keywords: proximal promoter; promoter; expression; p21 ... See more keywords
Genotoxic effects and proteomic analysis on Allium cepa var. agrogarum L. root cells under Pb stress
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DOI: 10.1007/s10646-020-02236-x
Abstract: Ionic lead (Pb) in the environment has accumulated due to anthropogenic activities, causing a potential threat to plants and plant consumers. We conducted this study to reveal the molecular mechanism of Pb stress response in… read more here.
Keywords: indicated decreased; agrogarum; genotoxic effects; expression ... See more keywords
Increased Expression of Translocator Protein (TSPO) Marks Pro-inflammatory Microglia but Does Not Predict Neurodegeneration
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-017-1099-1
Abstract: PurposeActivation of the innate immune system plays a significant role in pathologies of the central nervous system (CNS). In order to follow disease progression and evaluate effectiveness of potential treatments involved in neuroinflammation, it is… read more here.
Keywords: tspo; protein tspo; translocator protein; expression ... See more keywords
Steroid-resistant autoimmune myelofibrosis in a patient with autoimmune hepatitis and Evans syndrome complicated with increased expression of TGF-β in the bone marrow: a case report
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Hematology"
DOI: 10.1007/s12185-017-2268-3
Abstract: We here report a 47-year-old female with autoimmune myelofibrosis (AIMF) associated with liver damage caused by autoimmune hepatitis and Evans syndrome. Bone marrow biopsy revealed hypocellular marrow with grade 2 reticulin fibrosis and increased levels… read more here.
Keywords: autoimmune hepatitis; autoimmune myelofibrosis; bone marrow; marrow ... See more keywords
Increased expression of the fluorescent reporter protein ymNeonGreen in Saccharomyces cerevisiae by reducing RNA secondary structure near the start codon.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Reports"
DOI: 10.1016/j.btre.2021.e00697
Abstract: Highlights • Stable secondary RNA structure 3′ of the start codon inhibits ymNeonGreen expression.• Removing secondary RNA structure increased expression in S. cerevisiae and E. coli.• Expression was increased 2-fold in S. cerevisiae.• Expression was… read more here.
Keywords: fluorescent reporter; expression; start codon; increased expression ... See more keywords
Crohn's Colitis: Development of a multiplex gene expression assay comparing mRNA levels of susceptibility genes.
Sign Up to like & getrecommendations! Published in 2017 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2017.02.004
Abstract: Crohn's disease (CD) is a multifactorial immunologically mediated disease. In this study we explored, for the first time, the efficacy of the Multiplex Gene Assay technology for detecting mRNA expression profile of 24 selected CD… read more here.
Keywords: multiplex gene; response; expression genes; expression ... See more keywords
Increased expression of ALDH-1 is associated with clinical parameters of salivary glands neoplasms.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104552
Abstract: The enzyme aldehyde dehydrogenase-1 (ALDH-1) is a known putative tumour stem cells (TSC) marker, and these cells are implicated in carcinogenesis and progression of human neoplasms. We aimed to evaluate ALDH-1 expression in benign and… read more here.
Keywords: expression aldh; associated clinical; clinical parameters; salivary gland ... See more keywords
Increased expression of PD-1 and PD-L1 in oral lesions progressing to oral squamous cell carcinoma: a pilot study
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DOI: 10.1038/s41598-020-66257-6
Abstract: Oral cancer is a devastating disease and is commonly preceded by a range of oral premalignant disorders. We investigated the expression of PD-1 and PD-L1 in oral epithelial dysplasia (OED) that progressed to oral squamous… read more here.
Keywords: expression oral; cell carcinoma; oral squamous; squamous cell ... See more keywords
Corrigendum: Atrasentan increased the expression of klotho by mediating miR-199b-5p and prevented renal tubular injury in diabetic nephropathy
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DOI: 10.1038/srep46965
Abstract: This corrects the article DOI: 10.1038/srep19979. read more here.
Keywords: corrigendum atrasentan; atrasentan increased; expression klotho; klotho mediating ... See more keywords
Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2019.12.010
Abstract: BACKGROUND & AIMS Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that invades surrounding structures and metastasizes rapidly. Although inflammation is associated with tumor formation and progression, little is known about the mechanisms of this… read more here.
Keywords: tumor development; increased expression; mice; il22 ... See more keywords
Increased expression of pro‐inflammatory cytokines at the fetal–maternal interface in bovine pregnancies produced by cloning
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13520
Abstract: A significant rate of spontaneous abortion is observed in cattle pregnancies produced by somatic cell nuclear transfer (SCNT). Major histocompatibility complex class I (MHC‐I) proteins are abnormally expressed on the surface of trophoblast cells from… read more here.
Keywords: pregnancies produced; increased expression; cytokines fetal; inflammatory cytokines ... See more keywords