PRMT5 inhibition induces pro‐inflammatory macrophage polarization and increased hepatic triglyceride levels without affecting atherosclerosis in mice
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DOI: 10.1111/jcmm.17676
Abstract: Protein arginine methyltransferase 5 (PRMT5) controls inflammation and metabolism through modulation of histone methylation and gene transcription. Given the important role of inflammation and metabolism in atherosclerotic cardiovascular disease, here we examined the role of… read more here.
Keywords: increased hepatic; triglyceride levels; atherosclerosis; mice ... See more keywords
Metformin maintains intrahepatic triglyceride content through increased hepatic de novo lipogenesis
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Endocrinology"
DOI: 10.1530/eje-21-0850
Abstract: Objective Metformin is a first-line pharmacotherapy in the treatment of type 2 diabetes, a condition closely associated with non-alcoholic fatty liver disease (NAFLD). Although metformin promotes weight loss and improves insulin sensitivity, its effect on… read more here.
Keywords: intrahepatic triglyceride; novo lipogenesis; treatment; increased hepatic ... See more keywords