Abstract 2270: Combination of CXCR4 antagonist and anti-PD1 therapy results in significant mobilization and increased infiltration of myeloid cells into the metastatic liver microenvironment of PDAC
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DOI: 10.1158/1538-7445.am2023-2270
Abstract: Pancreatic adenocarcinoma (PDAC) is extremely lethal and resistant to checkpoint immunotherapy, characterized by an immunosuppressive tumor microenvironment consisting of stromal and myeloid cells. Prior studies have demonstrated the utility of targeting the chemokine signaling axis… read more here.
Keywords: cxcr4 antagonist; increased infiltration; myeloid cells; myeloid ... See more keywords