Mitochondrial dysfunction and increased reactive oxygen species production in MECP2 mutant astrocytes and their impact on neurons
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DOI: 10.1038/s41598-024-71040-y
Abstract: Studies on MECP2 function and its implications in Rett Syndrome (RTT) have traditionally centered on neurons. Here, using human embryonic stem cell (hESC) lines, we modeled MECP2 loss-of-function to explore its effects on astrocyte (AST)… read more here.
Keywords: rtt; increased reactive; dysfunction; oxygen species ... See more keywords