Demyelinating diseases as a result of cerebral edema?
Sign Up to like & getrecommendations! Published in 2017 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2017.05.010
Abstract: Due to the elastic properties of the human organs, tissue edema causes an increased tissue pressure. This phenomenon leads to a reduction of blood circulation or ischemia, and thus leads to the hypothesis that tissue… read more here.
Keywords: tissue pressure; tissue; edema; brain ... See more keywords
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.04.018
Abstract: Summary Duchenne muscular dystrophy (DMD) is a rare X-linked recessive disease that is associated with severe progressive muscle degeneration culminating in death due to cardiorespiratory failure. We previously observed an unexpected proliferation-independent telomere shortening in… read more here.
Keywords: dmd; telomere shortening; tissue stiffness; stiffness triggers ... See more keywords
Increased tissue factor activity promotes thrombin generation at type 1 diabetes onset in children
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Diabetes"
DOI: 10.1111/pedi.13086
Abstract: In type 1 diabetes (T1D), a prothrombotic status due to elevated coagulation factors coincides with metabolic derailment. In a previous study, we discovered altered thrombin generation profiles in children with T1D. These alterations are potentially… read more here.
Keywords: tissue factor; generation; type diabetes; thrombin generation ... See more keywords