Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00341
Abstract: Mitochondrial dysfunction is closely linked to the pathogenesis of neurodegenerative disorders, including prion diseases. SIRT3 is the major mitochondria NAD+ dependent deacetylase that acts as a regulator of mitochondrial protein function. Although SIRT3 was reported… read more here.
Keywords: aberrant decrease; increases acetylated; prion; decrease endogenous ... See more keywords