Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes
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DOI: 10.1038/s41598-018-22298-6
Abstract: Plants containing aristolochic acids (AA) are nephrotoxins. Glycine N-methyltransferase (GNMT) acts to bind environmental toxins such as benzo(a)pyrene and aflatoxin B1, translocate into nucleus, and alter hepatic metabolism. This study aims to determine the role… read more here.
Keywords: glycine methyltransferase; increasing cyp3a44; induced nephropathy; gnmt ... See more keywords