A systematic review and meta‐analysis of observational studies of the association between the use of incretin‐based therapies and the risk of pancreatic cancer
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DOI: 10.1002/pds.5550
Abstract: Some early reports in the medical literature have raised concern about a possible increased risk of pancreatic cancer associated with the use of two broad classes of incretin‐based therapies, dipeptidyl peptidase‐4 inhibitors, and glucagon‐like peptide‐1… read more here.
Keywords: incretin based; based therapies; pancreatic cancer; observational studies ... See more keywords
Renal Effects of Incretin-Based Diabetes Therapies: Pre-clinical Predictions and Clinical Trial Outcomes
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DOI: 10.1007/s11892-018-0991-7
Abstract: Purpose of ReviewThe purpose of this review is to correlate predictions based on pre-clinical data with outcomes from clinical trials that examine the effects of incretin-based diabetes treatments on the kidney. The incretin-based treatments include… read more here.
Keywords: incretin based; pre clinical; clinical trials; renal effects ... See more keywords
Incretin-based therapy in type 2 diabetes: An evidence based systematic review and meta-analysis.
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DOI: 10.1016/j.jdiacomp.2016.08.018
Abstract: Incretin based therapies such as dipeptidyl peptidase-4 inhibitors (DPP-4i) and glucagon-like peptide-1 receptor agonists (GLP-1Ra) are increasingly used for the treatment of Type 2 diabetes mellitus. In clinical practice and in previously performed clinical trials,… read more here.
Keywords: therapy; type diabetes; glp 1ra; incretin based ... See more keywords
Incretin-based therapies and renin-angiotensin system: Looking for new therapeutic potentials in the diabetic milieu.
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DOI: 10.1016/j.lfs.2020.117916
Abstract: Incretin-based therapies include pharmacologic agents such as glucagon like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors which exert potent anti-hyperglycemic effects in the diabetic milieu. They are also shown to have extra-pancreatic effects. Renin-angiotensin system… read more here.
Keywords: system; incretin based; based therapies; renin angiotensin ... See more keywords
Mast Cell and M1 Macrophage Infiltration and Local Pro-Inflammatory Factors Were Attenuated with Incretin-Based Therapies in Obesity-Related Glomerulopathy
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DOI: 10.1089/met.2017.0057
Abstract: Abstract Background: The global increase of obesity parallels the obesity-related glomerulopathy (ORG) epidemic. Dipeptidyl peptidase 4 inhibitors and glucagon-like peptide-1 receptor agonists were well recognized to attenuate renal injury independent of glucose control in diabetic… read more here.
Keywords: incretin based; based therapies; infiltration; macrophage ... See more keywords
Role of incretin‐based therapy in hospitalized patients with type 2 diabetes
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DOI: 10.1111/jdi.13130
Abstract: Evidence about the treatment of hospitalized type 2 diabetes patients with incretin‐based therapy has emerged in the past 15 years. Based on this evidence, dipeptidyl peptidase‐4 inhibitors should be considered for hospitalized patients with type… read more here.
Keywords: patients type; incretin based; type diabetes; based therapy ... See more keywords
Cognitive protection of incretin-based therapies in patients with type 2 diabetes mellitus: A systematic review and meta-analysis based on clinical studies.
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DOI: 10.1111/jdi.14015
Abstract: AIMS/INTRODUCTION Cognitive dysfunction, including mild cognitive impairment and dementia, is increasingly recognized as an important complication of type 2 diabetes mellitus. The aims of the preset study was to investigate the cognitive protection of incretin-based therapies,… read more here.
Keywords: incretin based; patients type; based therapies; type diabetes ... See more keywords
Systematic review of incretin therapy during peri-operative and intensive care
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DOI: 10.1186/s13054-018-2197-4
Abstract: BackgroundGlucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are incretin hormones. By lowering blood glucose in a glucose-dependent manner, incretin-based therapies represent a novel and promising intervention to treat hyperglycaemia in hospital settings. We… read more here.
Keywords: peri operative; incretin based; based therapies; systematic review ... See more keywords
Incretin-Based Therapies: Revisiting Their Mode of Action.
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DOI: 10.1210/en.2017-00252
Abstract: Brian T. Layden, Barton Wicksteed, and Franck Mauvais-Jarvis Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, Illinois 60612; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612; and… read more here.
Keywords: medicine; revisiting mode; incretin based; endocrinology ... See more keywords
The role of incretin-based therapies in the management of type 2 diabetes mellitus: perspectives on the past, present and future
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DOI: 10.14341/dm11493
Abstract: The ever-increasing burden of type 2 diabetes mellitus (T2DM) worldwide, has led to the emergence of several antidiabetes drugs with different modes of action. Incretin hormones and their effect on glucose metabolism and pathogenesis of… read more here.
Keywords: incretin based; based therapies; management; type diabetes ... See more keywords
Incretins and Lipid Metabolism.
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DOI: 10.2174/0929867324666170414164244
Abstract: BACKGROUND Recent findings indicate that incretin hormones and incretin-based therapies may affect the metabolism of lipoproteins, although the corresponding mechanisms are not clearly defined. OBJECTIVE To summarize the available data on the mechanisms linking incretins… read more here.
Keywords: production; incretin based; metabolism; glp ... See more keywords