2313-PUB: Alterations in Basal State of Insulin and mTOR-Dependent Signalings Closely Related to Impaired Incretin Profile and Type 2 Diabetes in Subcutaneous Adipose Tissue of Obese Patients
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DOI: 10.2337/db20-2313-pub
Abstract: Objective: In our study we have compared basal insulin and mTOR signaling in subcutaneous fat of obese T2DM vs. obese subjects with normal glucose tolerance (NGT). We have performed correlation analysis of phosphorylation’s parameters against… read more here.
Keywords: incretin profile; none; insulin mtor; insulin ... See more keywords
1287-PUB: SGK1-NDRG1 Signal Axis as a Key Marker Associated with Insulin Resistance and Impaired Incretin Profile in Subcutaneous and Omental Fat Depots among Obese Patients
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DOI: 10.2337/db21-1287-pub
Abstract: Objective: We have performed the comparative study of basal state of SGK-dependent signaling among obese patients with/without type 2 diabetes mellitus (T2DM). We have accomplished correlation analysis of glucose metabolism and incretin profile parameters against… read more here.
Keywords: incretin profile; omental fat; insulin resistance; fat depots ... See more keywords
NDRG1 Activity in Fat Depots Is Associated With Type 2 Diabetes and Impaired Incretin Profile in Patients With Morbid Obesity
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DOI: 10.3389/fendo.2021.777589
Abstract: Objective We aimed to investigate insulin-, mTOR- and SGK1-dependent signaling basal states in morbidly obese patients’ fat. We analyzed the correlation between the signaling activity, carbohydrate metabolism, and incretin profiles of patients. Methods The omental… read more here.
Keywords: correlation; type diabetes; pndrg1 t346; impaired incretin ... See more keywords