Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: Modulation of the cross talk between autophagy and apoptosis signaling.
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DOI: 10.1016/j.lfs.2021.119370
Abstract: BACKGROUND This study aimed to investigate the gastroprotective effect of chlorogenic acid (CGA) against Indomethacin (IND)-induced gastric ulcer (GU) in rats and its underlying mechanism, especially through autophagic and apoptotic pathways. METHODS Seventy-five rats were… read more here.
Keywords: apoptosis; ulcer rats; ind induced; gastric ulcer ... See more keywords
Gastric acid inhibitor aggravates indomethacin-induced small intestinal injury via reducing Lactobacillus johnsonii
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DOI: 10.1038/s41598-019-53559-7
Abstract: Proton pump inhibitors (PPIs) alter the composition of the intestinal microbiome, exacerbating indomethacin (IND)-induced small intestinal damage. Vonoprazan fumarate inhibits gastric acid secretion using a different mechanism from PPIs. We investigated the effects of both… read more here.
Keywords: small intestinal; induced small; ind induced; vonoprazan ... See more keywords