Synthesis, characterization and investigation of AChE and BuChE inhibitory activity of 1-alkyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium halide derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-019-01804-1
Abstract: Abstract The design, synthesis and characterization of a series of 1-alkyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium halide derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors for the treatment of Alzheimer’s disease were reported. The strategy for this synthesis was based on aldol… read more here.
Keywords: alkyl dimethoxy; buche; dimethoxy indanone; methylene ... See more keywords
Synthesis and structural revision of an indanone isolated from Triphyophyllum peltatum
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151494
Abstract: Abstract In this paper, skeletal rearrangements of 2-hydroxy-3-methyl-1,4-naphthoquinones to indanones are reported. The application of this reaction to the synthesis of an indanone isolated from root cultures of the West African liana Triphyophyllum peltatum is… read more here.
Keywords: synthesis structural; structural revision; indanone; indanone isolated ... See more keywords
Dinuclear Zinc-Catalyzed Asymmetric Tandem Reaction of α-Hydroxy-1-indanone: Access to Spiro[1-indanone-5,2'-γ-butyrolactones].
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02658
Abstract: A highly efficient method for the enantioselective build of spiro[1-indanone-5,2'-γ-butyrolactones] has been developed through the tandem Michael/transesterification reaction of α-hydroxy-1-indanone and α,β-unsaturated esters. A broad range of spiro(1-indanone-butyrolacones) with contiguous stereocenters have been synthesized with… read more here.
Keywords: hydroxy indanone; spiro indanone; reaction hydroxy; indanone butyrolactones ... See more keywords
Methoxy substituted 2-benzylidene-1-indanone derivatives as A1 and/or A2A AR antagonists for the potential treatment of neurological conditions.
Sign Up to like & getrecommendations! Published in 2019 at "MedChemComm"
DOI: 10.1039/c8md00540k
Abstract: A prior study reported on hydroxy substituted 2-benzylidene-1-indanone derivatives as A1 and/or A2A antagonists for the potential treatment of neurological conditions. A lead compound (1a) was identified with both A1 and A2A affinity in the… read more here.
Keywords: a2a antagonists; methoxy substituted; benzylidene indanone; substituted benzylidene ... See more keywords
Recent advances in transition-metal-catalyzed annulations for the construction of a 1-indanone core
Sign Up to like & getrecommendations! Published in 2021 at "New Journal of Chemistry"
DOI: 10.1039/d0nj06318e
Abstract: Indanone-containing scaffolds are attractive synthetic targets because of their wide occurrence in many natural products, drugs and functional materials. In the last few years, enormous efforts have been devoted to the development of the 1-indanone… read more here.
Keywords: transition metal; indanone; construction indanone; indanone core ... See more keywords