New indole and indazole derivatives as potential antimycobacterial agents
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02293-w
Abstract: AbstractThe study reports on the synthesis and in vitro assessment of the antimycobacterial activity of a series of new indole- and indazole-based aroylhydrazones evaluated against Mycobacterium tuberculosis H37Rv. Isoniazide and ethambutol were used as reference… read more here.
Keywords: indole indazole; antimycobacterial activity; new indole; indazole derivatives ... See more keywords
Novel strategy for the preparation of 3-perfluoroalkylated-2H-indazole derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.03.051
Abstract: Abstract A simple and novel methodology for the synthesis of 3-perfluoroalkylated-2H-indazole derivatives has been elaborated. The perfluoroalkylation of readily available 2-nitrobenzaldimines bearing electron donating groups was performed using the Ruppert-Prakash reagent and its analogues to… read more here.
Keywords: methodology; preparation perfluoroalkylated; perfluoroalkylated indazole; indazole derivatives ... See more keywords
Synthesis and biological evaluation of indazole derivatives as anti-cancer agents
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra01147b
Abstract: One of the synthesized indazole derivatives, 2f, displayed inhibitory activities against proliferation, migration and invasion of breast cancer cell line 4T1, with the potential of inducing cell apoptosis, and suppressing tumor growth in vivo. read more here.
Keywords: cancer; indazole derivatives; evaluation indazole; synthesis biological ... See more keywords
Molecular dynamics and 3D-QSAR studies on indazole derivatives as HIF-1α inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2051745
Abstract: Abstract Hypoxia-inducible factor (HIF) is a transcriptional factor which plays a crucial role in tumour metastasis thereby responsible for development of various forms of cancers. Indazole derivatives have been reported in the literature as potent… read more here.
Keywords: qsar studies; inhibitors molecular; indazole derivatives; molecular dynamics ... See more keywords
Multitarget drugs as potential therapeutic agents for alzheimer’s disease. A new family of 5-substituted indazole derivatives as cholinergic and BACE1 inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2117315
Abstract: Abstract Multitarget drugs are a promising therapeutic approach against Alzheimer’s disease. In this work, a new family of 5-substituted indazole derivatives with a multitarget profile including cholinesterase and BACE1 inhibition is described. Thus, the synthesis… read more here.
Keywords: substituted indazole; indazole derivatives; alzheimer disease; family substituted ... See more keywords
Indazole and its derivatives in cardiovascular diseases: Overview, current scenario and future perspectives.
Sign Up to like & getrecommendations! Published in 2021 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026621666211214151534
Abstract: Indazoles are a class of heterocyclic compounds with a bicyclic ring structure composed of a pyrazole ring and a benzene ring. Indazole-containing compounds with various functional groups have important pharmacological activities and can be used… read more here.
Keywords: current scenario; indazole derivatives; derivatives cardiovascular; cardiovascular diseases ... See more keywords
Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug
Sign Up to like & getrecommendations! Published in 2020 at "Applied Sciences"
DOI: 10.3390/app10113792
Abstract: A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches. The as-prepared indazole derivatives (3a–3j) and their N-methyl derivatives… read more here.
Keywords: synthesis indazole; derivatives potent; potent anticancer; pph3 catalyzed ... See more keywords
Synthesis, Antiprotozoal Activity, and Cheminformatic Analysis of 2-Phenyl-2H-Indazole Derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26082145
Abstract: Indazole is an important scaffold in medicinal chemistry. At present, the progress on synthetic methodologies has allowed the preparation of several new indazole derivatives with interesting pharmacological properties. Particularly, the antiprotozoal activity of indazole derivatives… read more here.
Keywords: phenyl indazole; synthesis antiprotozoal; antiprotozoal activity; indazole derivatives ... See more keywords
Identification and development of novel indazole derivatives as potent bacterial peptidoglycan synthesis inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Mycobacteriology"
DOI: 10.4103/ijmy.ijmy_201_17
Abstract: Background: Tuberculosis is well-known airborne disease caused by Mycobacterium tuberculosis. Available treatment regimen was unsuccessful in eradicating the deaths caused by the disease worldwide. Owing to the drawbacks such as prolonged treatment period, side effects,… read more here.
Keywords: identification development; novel indazole; derivatives potent; potent bacterial ... See more keywords